Gastroesophageal reflux in severe cases of Robin sequence treated with nasopharyngeal intubation

Ilza Lazarini Marques1, Luiz Carlos Silveira Monteiro, Luiz de Souza

  • 1Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru, Brazil. marquesi@usp.br

Insights

Infants with Robin sequence experience higher rates of abnormal gastroesophageal reflux. Nonsurgical treatments effectively improved breathing and feeding issues in most infants, indicating a positive treatment outcome.

Area of Science:

  • Pediatric Gastroenterology
  • Craniofacial Anomalies
  • Neonatal Care

Background:

  • Robin sequence often presents with severe respiratory obstruction, necessitating interventions like nasopharyngeal intubation.
  • Gastroesophageal reflux is a potential complication in infants, particularly those with craniofacial abnormalities.
  • Understanding reflux prevalence is crucial for managing infants with Robin sequence.

Purpose of the Study:

  • To determine the prevalence of abnormal gastroesophageal reflux in infants with severe Robin sequence.
  • To assess the effectiveness of nonsurgical interventions for respiratory and feeding difficulties in these infants.

Main Methods:

  • A longitudinal prospective study involving 20 infants with severe isolated Robin sequence.
  • 24-hour esophageal pH monitoring was conducted at 2, 4, and 6 months of age.
  • Respiratory and feeding statuses were evaluated alongside reflux index measurements.

Main Results:

  • The initial prevalence of abnormal gastroesophageal reflux (reflux index > 95th percentile) was significantly higher (6/20) compared to normal infants (p < .01).
  • Reflux index values decreased in subsequent evaluations.
  • Ninety percent of infants demonstrated improved respiratory function and achieved oral feeding capacity.

Conclusions:

  • Infants with severe Robin sequence exhibit a higher prevalence of abnormal gastroesophageal reflux.
  • Nonsurgical management strategies were effective in ameliorating respiratory and feeding challenges for the majority of these infants.
Abstract

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