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Gastroesophageal reflux in severe cases of Robin sequence treated with nasopharyngeal intubation
Ilza Lazarini Marques1, Luiz Carlos Silveira Monteiro, Luiz de Souza
1Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru, Brazil. marquesi@usp.br
Insights
Infants with Robin sequence experience higher rates of abnormal gastroesophageal reflux. Nonsurgical treatments effectively improved breathing and feeding issues in most infants, indicating a positive treatment outcome.
Area of Science:
- Pediatric Gastroenterology
- Craniofacial Anomalies
- Neonatal Care
Background:
- Robin sequence often presents with severe respiratory obstruction, necessitating interventions like nasopharyngeal intubation.
- Gastroesophageal reflux is a potential complication in infants, particularly those with craniofacial abnormalities.
- Understanding reflux prevalence is crucial for managing infants with Robin sequence.
Purpose of the Study:
- To determine the prevalence of abnormal gastroesophageal reflux in infants with severe Robin sequence.
- To assess the effectiveness of nonsurgical interventions for respiratory and feeding difficulties in these infants.
Main Methods:
- A longitudinal prospective study involving 20 infants with severe isolated Robin sequence.
- 24-hour esophageal pH monitoring was conducted at 2, 4, and 6 months of age.
- Respiratory and feeding statuses were evaluated alongside reflux index measurements.
Main Results:
- The initial prevalence of abnormal gastroesophageal reflux (reflux index > 95th percentile) was significantly higher (6/20) compared to normal infants (p < .01).
- Reflux index values decreased in subsequent evaluations.
- Ninety percent of infants demonstrated improved respiratory function and achieved oral feeding capacity.
Conclusions:
- Infants with severe Robin sequence exhibit a higher prevalence of abnormal gastroesophageal reflux.
- Nonsurgical management strategies were effective in ameliorating respiratory and feeding challenges for the majority of these infants.
Objective:
To study the prevalence of abnormal gastroesophageal reflux in infants with Robin sequence who had severe respiratory obstruction treated with nasopharyngeal intubation and to evaluate the efficacy of nonsurgical treatment.
Design:
Longitudinal prospective study.
Setting:
Hospital de Reabilitação de Anomalias Craniofaciais, University of São Paulo, Brazil.
Patients:
Twenty infants with severe isolated Robin sequence treated with nasopharyngeal intubation.
Interventions:
We performed 24-hour esophageal pH monitoring on each child at 2, 4, and 6 months of age. Respiratory and feeding status were evaluated. We considered abnormal gastroesophageal reflux as reflux index values above the 95th percentile of the Vandenplas reference for normal children.
Results:
The prevalence of reflux index above the 95th percentile at the first exam was 6/20, a value significantly higher than the reference (5/103, p < .01). At the second and third exams, reflux index values were decreased. Ninety percent of the infants showed improvement of respiratory difficulty and developed oral feeding capacity.
Conclusions:
The prevalence of abnormal gastroesophageal reflux is higher in infants with severe cases of Robin sequence than in normal infants. Nonsurgical procedures improved respiratory and feeding difficulties of most of these infants.
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