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Effect of lymphokines on beta-adrenoceptor stimulation of human PBMC
A J Van Oosterhout1, W B Stam, F P Nijkamp
1Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Agents and Actions. Supplements
|January 1, 1990
Abstract:
The effect of IL-2, IL-3, IL-4 and GM-CSF on beta-adrenoceptor function of human peripheral blood mononuclear cells (PBMC) was studied. After a 2 h pre-incubation period of PBMC with each of the lymphokines (1-100 units/ml), the isoprenaline stimulated cAMP production in these cells was not altered. However, IL-2 and GM-CSF induced a concentration dependent decrease of the beta-adrenoceptor agonist stimulated cAMP production after a 20 h pre-incubation period.