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Updated: Jun 21, 2026
10:14
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
It's not over till the last glomerulus forms.
Rosemary Thomas1, Frederick J Kaskel
1Division of Pediatric Nephrology, Albert Einstein College of Medicine/Children's Hospital at Montefiore, Bronx, New York 10467, USA.
Kidney International
|August 1, 2009
Summary
Premature infants with extrauterine growth retardation (EUGR) show reduced kidney function. This highlights the importance of early nutrition for long-term kidney health in vulnerable newborns.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Developmental Biology
Background:
- The Brenner hypothesis links low birth weight to adult chronic kidney disease.
- Extrauterine growth retardation (EUGR) in premature infants is poorly understood regarding its impact on adult kidney health.
Discussion:
- Bacchetta et al. investigated the renal function of premature infants experiencing EUGR.
- Inulin clearance was used to assess glomerular filtration rate, revealing impaired renal function.
Key Insights:
- Premature infants with EUGR exhibit decreased renal function.
- This finding suggests EUGR may have lasting consequences on kidney health.
- Early nutritional interventions may be crucial for nephrogenesis.
Outlook:
- Further research is needed to explore the long-term renal outcomes for premature infants with EUGR.
- Investigating optimal protein nutrition strategies during neonatal development is essential.
- Understanding the timing of nephrogenesis in relation to EUGR can inform clinical practice.
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