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Optimal biphasic waveforms for internal defibrillation using a 60 muF capacitor.

Yoshio Yamanouchi¹, Stéphane X Garrigue, Kent A Mowrey

¹Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Experimental and Clinical Cardiology

|August 1, 2009

Summary

This summary is machine-generated.

Optimal biphasic waveforms for defibrillation were identified. A 40% to 50% phase 1 tilt in 60/60 muF capacitors maximizes efficacy, and a 15 muF capacitor in phase 2 further reduces energy.

Keywords:

Biphasic waveform Internal defibrillation Small capacitor

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Published on: December 11, 2017

Area of Science:

Biomedical Engineering
Cardiovascular Research
Medical Device Technology

Background:

Theoretical models suggest 40-80 muF capacitance is optimal for defibrillation.
A 60 muF capacitor is considered optimal for maximizing defibrillation efficacy and reducing energy.
Biphasic waveforms are commonly used in defibrillation devices.

Purpose of the Study:

To determine the optimal phase 1 tilt for maximizing defibrillation efficacy in a 60/60 muF biphasic waveform.
To compare the efficacy of optimized 60/60 muF biphasic waveforms with a 60/15 muF biphasic waveform.
To evaluate the impact of phase 1 tilt on defibrillation thresholds (DFTs).

Main Methods:

Evaluated five 60/60 muF biphasic waveforms with varying phase 1 tilts (40%-80%) and one 60/15 muF waveform (50% tilt).
Used a hot can electrode system in 15 pigs (20+/-2 kg) to assess defibrillation thresholds.
Employed the 'down-up, down-up' technique for random DFT measurement with constant 3 ms phase 2 pulse widths.

Main Results:

The 60/60 muF biphasic waveforms with 40% and 50% phase 1 tilt showed the lowest DFT energy (6.9*), not significantly different from each other.
Higher phase 1 tilts (60%, 70%, 80%) in 60/60 muF waveforms resulted in significantly higher DFT energy (7.1*, 7.8*, 8.4*).
The 60/15 muF waveform (50% tilt) demonstrated the lowest DFT energy (6.0), indicating higher efficacy.

Conclusions:

A phase 1 tilt of 40% to 50% optimizes defibrillation efficacy for 60/60 muF biphasic waveforms.
Utilizing a 15 muF capacitor for phase 2 can further decrease defibrillation energy requirements.
These findings contribute to optimizing biphasic waveform parameters for enhanced defibrillation effectiveness.