Related Experiment Video
Updated: Jun 21, 2026
08:50
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Maternal nativity as a risk factor for gastroschisis: a population-based study.
Jason L Salemi1, Marie Pierre, Jean Paul Tanner
1Birth Defects Surveillance Program, University of South Florida, Tampa, Florida, USA.
Summary
Gastroschisis risk is rising globally. This study found that in Florida, factors beyond young maternal age, including race/ethnicity and nativity, are significantly associated with gastroschisis risk.
Area of Science:
- Perinatal epidemiology
- Birth defects research
- Public health surveillance
Background:
- Gastroschisis prevalence is increasing worldwide, with unclear etiology.
- Young maternal age is the primary identified risk factor.
- The role of maternal nativity in gastroschisis risk requires further investigation.
Purpose of the Study:
- To examine the association between maternal nativity and gastroschisis risk.
- To investigate other potential risk factors for gastroschisis in Florida.
- To understand factors contributing to the rising prevalence of gastroschisis.
Main Methods:
- Retrospective cohort study of singleton births in Florida (1998-2003).
- Gastroschisis cases identified via the Florida Birth Defects Registry.
- Multivariable Poisson regression analysis to calculate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs).
Main Results:
- The birth prevalence of gastroschisis was 3.26 per 10,000 live births, with a 41% annual increase.
- Maternal race/ethnicity and nativity were significantly associated with gastroschisis risk.
- Non-Hispanic Black and Hispanic women, and women born outside the U.S., had lower gastroschisis risk compared to non-Hispanic white, U.S.-born women.
Conclusions:
- Young maternal age is a significant risk factor for gastroschisis.
- Maternal race/ethnicity and nativity are important factors that may help explain the increasing prevalence of gastroschisis.
- Further research into these demographic factors is warranted to elucidate gastroschisis etiology.
Related Concept Videos
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...