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Fludarabine, cyclophosphamide, mitoxantrone plus rituximab (FCM-R) in frontline CLL <70 Years
Stefan Faderl1, William Wierda, Susan O'Brien
1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. sfader@mdanderson.org
Leukemia Research
|August 4, 2009
Abstract:
Randomized trials demonstrated the superiority of chemoimmunotherapy over chemotherapy in the frontline treatment of CLL. Based on favorable experience with the addition of mitoxantrone (M) to fludarabine (F) plus cyclophosphamide (C), we designed a pilot study testing the combination of FCM plus rituximab (R). Thirty patients with previously untreated, symptomatic CLL, <70 years, and beta-2-microglobulin
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