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Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems
Published on: April 23, 2012
Disinfection efficacy against parvoviruses compared with reference viruses
M Eterpi1, G McDonnell, V Thomas
1STERIS SA R&D, Fontenay-aux-Roses, France.
The Journal of Hospital Infection
|August 4, 2009
Summary
Porcine parvovirus (PPV) showed high resistance to common disinfectants when dried on surfaces. This highlights the need for effective disinfection strategies against resistant viruses to prevent disease transmission.
Area of Science:
- Virology
- Infectious Diseases
- Disinfection Science
Background:
- Viruses can survive on surfaces, posing transmission risks.
- Disinfectant efficacy against dried viruses, especially resistant non-enveloped types like parvoviruses, is understudied.
- Emerging pathogenic viruses necessitate robust disinfection validation.
Purpose of the Study:
- To evaluate the effectiveness of common biocides against dried viruses.
- To identify highly resistant virus surrogates for disinfection testing.
- To inform disinfection protocols for preventing nosocomial transmission.
Main Methods:
- Tested biocides (including heat) against dried porcine parvovirus (PPV), minute virus of mice, poliovirus type 1, adenovirus type 5, and vaccinia virus.
- Assessed disinfectant activity on virus dried onto surfaces.
- Identified the most resistant viral species.
Main Results:
- Porcine parvovirus (PPV) exhibited the highest resistance to tested biocides.
- Many disinfectants effective against non-enveloped viruses showed limited activity against PPV.
- Ethanol demonstrated poor efficacy against all tested non-enveloped viruses.
Conclusions:
- Porcine parvovirus (PPV) is a highly resistant surrogate for disinfection studies.
- Disinfection products require validation against dried viruses.
- Effective strategies are crucial to prevent transmission of resistant viruses like parvoviruses.
