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Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis

Irena Martin-Kleiner1, Koraljka Gall Troselj

  • 1Division of Molecular Medicine, Rudjer Bosković Institute, Zagreb, Croatia.

Cancer Letters
|August 4, 2009
PubMed

Insights

The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is vital in normal cell function and cancer. This review highlights over 25 years of research on M6P/IGF2R

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Receptor Biology

Background:

  • The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor implicated in numerous cellular processes.
  • Dysregulation of M6P/IGF2R function is observed in various cancers, suggesting a role in tumorigenesis.
  • Despite its recognized tumor suppressor activity, the full scope of M6P/IGF2R's involvement in normal physiology and carcinogenesis remains complex due to its multifaceted nature.

Purpose of the Study:

  • To provide a focused review of M6P/IGF2R research over the past 25 years.
  • To critically analyze the role of M6P/IGF2R in normal cellular physiology and its implications in cancer.
  • To consolidate understanding of M6P/IGF2R's complex functions in the context of carcinogenesis.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of data from over 25 years of cancer research focused on M6P/IGF2R.
  • Synthesis of information on M6P/IGF2R's involvement in cellular processes and cancer.

Main Results:

  • M6P/IGF2R plays a significant role in diverse cellular functions.
  • Its dysregulation is a recurring theme in cancer development.
  • Decades of research underscore its complex involvement in both normal physiology and cancer.

Conclusions:

  • M6P/IGF2R is a critical receptor with a well-established tumor suppressor role.
  • Understanding its multifunctionality is key to fully elucidating its role in carcinogenesis.
  • Continued research is essential to unravel the complete impact of M6P/IGF2R on cancer biology.

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