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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dosimetric parameters in partial breast irradiation through brachytherapy.

Aime Gloi¹, Steve McCourt, Robert Buchanan

¹Department of Radiation Oncology, St. Vincent, Green Bay, WI 54301, USA. agloi@stvgb.org

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists

|August 4, 2009

Summary

This study evaluated the MammoSite RTS partial breast irradiation method for early-stage breast cancer. Results show high tumor control probability and low complication probability, indicating suitability for treatment planning.

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Oncology
Radiotherapy
Medical Physics

Background:

Partial breast irradiation (PBI) is an alternative to whole breast irradiation for early-stage breast cancer.
The MammoSite Radiation Therapy System (RTS) is a brachytherapy device for PBI.

Purpose of the Study:

To evaluate biological models and dose homogeneity for the MammoSite RTS partial breast irradiation method.
To assess tumor control probability (TCP) and normal tissue complication probability (NTCP) in patients treated with MammoSite RTS.

Main Methods:

Eleven patients with early-stage invasive ductal breast cancer were treated with MammoSite RTS brachytherapy using an Iridium-192 source.
Dose volume distributions were determined, and dosimetric, TCP, and NTCP parameters were calculated.
Correlations between parameters like dose homogeneity indices and area under the dose-volume histogram (DVH) were analyzed.

Main Results:

The average equivalent uniform dose (EUD) was 43.66 Gy, with average NTCP of 47.95% and TCP of 91.78%.
Low coefficient of variation (CV) was observed for EUD, NTCP, and TCP across patients.
Strong correlations were found between dose homogeneity indices (DHI, S-index) and between the area under the DVH and treatment volume (TXV).

Conclusions:

A simplified logit Poisson-EUD model is effective for determining NTCP and TCP.
The MammoSite RTS method demonstrates favorable dosimetric and biological parameters for early breast cancer treatment.
Dose homogeneity indices and DVH parameters are valuable for radiotherapy treatment planning.