Related Experiment Video
Updated: Jun 21, 2026
06:36
A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
Published on: December 10, 2021
New indications for artificial collagen-elastin matrices? Covering exposed tendons
Tino Wetzig1, Carl Gebhardt, Jan C Simon
1Department of Dermatology, Venereology and Allergology, Universitatsklinikum Leipzig A.o.R., Leipzig, Germany. wett@medizin.uni-leipzig.de
Dermatology (Basel, Switzerland)
|August 4, 2009
Summary
A collagen-elastin matrix combined with a skin graft effectively repaired a hand defect after tumor removal. This one-step procedure promoted quick healing and restored function and appearance.
Area of Science:
- Plastic Surgery
- Regenerative Medicine
Background:
- Surgical defects involving exposed tendons require advanced reconstructive techniques.
- Micrographic controlled tumor excision can result in complex defects needing specialized closure.
Observation:
- An 80-year-old patient developed a hand dorsum defect with exposed tendons post-tumor excision.
- The defect presented a significant challenge for standard wound closure methods.
Findings:
- A one-step reconstruction using an artificial collagen-elastin matrix (Matriderm) covered by an autologous split-skin graft was performed.
- This combined approach facilitated rapid wound healing.
- Excellent functional and cosmetic outcomes were achieved.
Implications:
- This technique offers a viable solution for complex hand defects.
- The use of combined matrix and graft promotes faster recovery and better aesthetic results in reconstructive surgery.
Related Concept Videos
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
01:42The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.