[A comparative study of the invasive potential of 6 human lung carcinoma cell lines and its relation to laminin]

The purpose of this paper is to compare and research on the invasive potential of 6 human lung carcinoma cell lines and its relationship to LN. The results indicate that one pulmonary giant cell carcinoma cell line and one pulmonary low differentiated squamous cell carcinoma cell line have endogenous LN. Both cell lines have the highest adhesiveness and motility in vitro and the highest invasiveness in vivo. The adhesiveness and motility of one pulmonary low differentiated squamous carcinoma cell line and two pulmonary adenocarcinoma cell lines were enhanced by exogenous LN. However, one pulmonary carcinoma cell line which is LN negative and not reactive to exogenous LN has the lowest adhesiveness and motility in vitro and the lowest invasiveness in vivo. These results indicate that the invasive potential of the six pulmonary carcinoma cell lines is quite different from reach other which is closely related to LN.