Related Experiment Video
Updated: Jun 21, 2026

Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
Published on: April 15, 2016
L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala
Elodie Fourcaudot1, Frederic Gambino, Guillaume Casassus
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Abstract:
The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca(2+) channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC-mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.
Related Concept Videos
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Role of Amygdala in Memory
One of the...

