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Updated: Jun 21, 2026

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
[New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle]
José Rodrigo Pauli1, Dennys Esper Cintra, Claudio Teodoro de Souza
1Departamento de Biociências, Faculdade de Educação Física, modalidade Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil. rodrigosere@yahoo.com.br
Abstract:
Insulin resistance of skeletal muscle glucose transport is a key-defect for the development of impaired glucose tolerance and type 2 diabetes. However, it is known that both an acute bout of exercise and chronic endurance exercise training can bring beneficial effects on insulin action in insulin-resistant states. However, little is currently known about the molecular effects of acute exercise on muscle insulin signaling in the post-exercise state in insulin-resistant organisms. This review provides new insight into the mechanism through which acute exercise restores insulin sensitivity, highlighting an important role for inflammatory proteins and S-nitrosation in the regulation of insulin signaling proteins in skeletal muscle.
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