Related Experiment Video
Updated: Jun 21, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced beta-cell function in
Daniela Saes Sartorelli1, Laércio Joel Franco, Renata Damião
1Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. daniss@fmrp.usp.br
Objective:
To investigate the association between carbohydrate intakes and beta-cell function (HOMA-beta) in Japanese-Brazilians with impaired glucose tolerance (IGT).
Methods:
Dietary intakes were assessed by a validated food frequency questionnaire in a cross-sectional survey carried out in 2000. The associations between diet and HOMA-beta were verified in 270 newly diagnosed IGT in multiple linear regression models.
Results:
The mean (SD) age was 58 (11) years and the mean HOMA-beta was 65 (47). The glycemic load was inversely associated with HOMA-beta, beta1 -0.140 (95%CI = -1.044; -0.078), p = 0.023. The inverse association was also observed for refined grains intakes: -0.186 (95%CI = -0.4862; -0.058), p = 0.012. After adjustments for body mass index, the glycemic index was inversely associated with HOMA-beta: -0.1246 (95%CI = -2.2482, -0.0257), p < 0.001.
Conclusions:
These data suggested that dietary glycemic load, glycemic index, and refined grains intakes are associated with reduced beta-cell function, and the quality of dietary carbohydrates may be relevant for maintaining beta-cell function among individuals with IGT.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Type II Diabetes II: Pathophysiology
Type I Diabetes II: Pathophysiology
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
