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Related Concept Videos

Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
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Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not observed.

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Related Experiment Video

Updated: Jun 21, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

Asymmetric synthesis for process research.

C H Senanayake1, D Krishnamurthy

  • 1Sepracor Inc, 111 Locke Drive, Marlborough, MA 01752, USA. csenanay@sepracor.com

Current Opinion in Drug Discovery & Development
|August 4, 2009
PubMed
Summary
This summary is machine-generated.

Asymmetric synthesis is crucial for producing enantiopure materials. This review highlights recent advancements in efficient, reliable, and economically viable asymmetric synthesis technologies for process research and development.

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Last Updated: Jun 21, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
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Published on: October 6, 2023

Area of Science:

  • Organic Chemistry
  • Process Chemistry

Background:

  • Asymmetric synthesis is vital for creating enantiopure compounds.
  • Current methods often lack efficiency, reliability, or economic viability.
  • Demand for advanced asymmetric synthesis technologies is increasing.

Purpose of the Study:

  • To review recent literature (Jan 1998-Aug 1999) on asymmetric synthesis.
  • To identify impactful advancements for process research and development.
  • To highlight efficient, reliable, and economically viable synthetic strategies.

Main Methods:

  • Literature review of scientific articles.
  • Focus on publications from January 1998 to August 1999.
  • Analysis of methods impacting asymmetric synthesis in process R&D.

Main Results:

  • Identification of several promising asymmetric synthesis articles.
  • Overview of techniques with potential for industrial application.
  • Highlighting progress in enantiopure material production.

Conclusions:

  • Recent developments show significant potential to advance asymmetric synthesis.
  • Continued research is needed to develop truly efficient and economical methods.
  • The reviewed literature offers valuable insights for process research and development.