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Updated: Jun 21, 2026

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
Published on: March 30, 2022
The structural basis of matrix metalloproteinase inhibition
1Roche Discovery Welwyn, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AY, UK. neera.borkakoti@roche.com
Abstract:
Over the last decade, the potential utility of matrix metalloproteinase (MMP) inhibitors as novel therapeutic agents for diseases such as arthritis, cancer and multiple sclerosis has lead to an abundance of three-dimensional structural information on this family of enzymes. This review describes the spatial features of the conserved three-dimensional scaffold of the MMPs, discusses enzyme-inhibitor interactions and relates these data to the characteristics of individual MMPs which influence the potency and selectivity of inhibitors.
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