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Updated: Jun 21, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease
Rodrigo V Wainstein1, Marco V Wainstein, Jorge P Ribeiro
1Cardiology Division of Hospital de Clinicas de Porto Alegre, Brazil. rodrigo.wainstein@uhn.on.ca
Objectives:
Myeloperoxidase (MPO) polymorphism -463 has been related to higher cardiovascular risk. This study was conducted to test whether the MPO promoter polymorphism -463A/G and MPO plasma levels are associated with coronary artery disease (CAD) severity.
Design And Methods:
Patients submitted to elective coronariography were enrolled, CAD severity was assessed and blood samples collected to identify the MPO polymorphism and its plasma levels.
Results:
Genotypes were determined in 118 patients. Among these patients, 12 (10%) were homozygous for AA, 69 (58%) for GG and 37 (32%) were heterozygous. Mean MPO plasma levels were 8.6+/-4.7 ng/mL for AA, 8.6+/-7.0 ng/mL for AG and 9.4+/-5.6 ng/mL for GG genotypes. The CAD severity was not associated with MPO genotypes (p=0.43), however, patients with higher CAD score presented higher MPO levels (p=0.02).
Conclusion:
We found no association between MPO polymorphism and CAD severity, although a relation was observed for MPO plasma levels and extension of CAD.
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