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Updated: Jun 21, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Health economics and RSV
Xavier Carbonell-Estrany1, Pablo Lázaro y de Mercado
1Hospital Clinic-Maternitat, Institut Clinic de Ginecologia, Obstetricia Neonatologia, Barcelona, Spain. XCARBO@clinic.ub.es
Abstract:
An economic analysis was performed in Spain to evaluate the efficiency (cost-effectiveness) of palivizumab in preventing severe RSV infection in premature infants with GA 32-35 and two or more risk factors (RF). The design was a decision tree model using data from the scientific literature and the FLIP I and FLIP II studies IRIS Study Group. The main effectiveness measure was quality-adjusted life years (QALY) gained from both the National Health System (NHS) and societal perspectives. Prophylaxis with palivizumab was found to produce an incremental cost-effectiveness ratio (ICER) of 13,849euro/QALY from the NHS perspective, and 4,605euro/QALY from the societal perspective. Palivizumab is a cost-effective therapy as prophylaxis against RSV in infants with GA 32-35 and two or more RF. Its use is efficient from the NHS perspective, since the cost of a QALY, even in the least favourable scenarios, is lower than the threshold of 30,000euro/QALY considered socially acceptable in Europe.
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