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Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: the Generation R Study

Ankie Lebon1, Joost A M Labout, Henri A Verbrugh

  • 1Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, University Medical Center, PO Box 2060, 3000 CB Rotterdam, The Netherlands. h.a.moll@erasmusmc.nl

Archives of Pediatrics & Adolescent Medicine
|August 5, 2009
PubMed

Insights

Staphylococcus aureus nasal colonization in infants at 6 months is linked to atopic dermatitis (AD) and its severity. Frequent colonization in the first year increases the risk of moderate to severe AD.

Area of Science:

  • Pediatric Dermatology
  • Microbiology
  • Epidemiology

Background:

  • Atopic dermatitis (AD) is a common inflammatory skin condition in infants.
  • The role of Staphylococcus aureus (S. aureus) nasal colonization in AD development is under investigation.

Purpose of the Study:

  • To investigate the association between Staphylococcus aureus nasal colonization and the development and severity of atopic dermatitis in infancy.

Main Methods:

  • A population-based prospective cohort study involving 1079 Dutch infants.
  • Nasal swabs for S. aureus cultivation were collected at 1.5, 6, and 14 months.
  • Atopic dermatitis and confounders were assessed via questionnaires throughout the first two years of life.

Main Results:

  • A positive S. aureus culture at 6 months was associated with increased AD prevalence and severity in the first and second years.
  • Frequent colonization (≥2 times) in the first year correlated with a 4.29-fold increased risk of moderate to severe AD in the second year.

Conclusions:

  • Infant Staphylococcus aureus nasal colonization at 6 months is associated with atopic dermatitis.
  • Frequent colonization in the first year of life is linked to increased risk and severity of AD in young children.
Abstract

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