Initial experience with the new Amplatzer Duct Occluder II

Area of Science:

• Cardiology
• Interventional Cardiology
• Pediatric Cardiology

Background:

• Transcatheter occlusion of patent ductus arteriosus (PDA) utilizes various devices with limitations.
• The Amplatzer Duct Occluder II (ADO II) was developed to address existing challenges in PDA closure.

Purpose of the Study:

• To evaluate the initial single-center experience with the novel Amplatzer Duct Occluder II (ADO II) for transcatheter PDA occlusion.

Main Methods:

• Ten consecutive patients with PDA (minimal diameter ≥ 2 mm) were enrolled for ADO II treatment.
• Patient demographics included a median age of 10.2 years and median weight of 35.5 kg.

Main Results:

• Successful ADO II implantation was attempted in all 10 patients.
• Complete closure was achieved in 8/8 ADO II implantations and in one patient treated with a coil.
• One patient required device change to Amplatzer Duct Occluder I due to left pulmonary artery encroachment; no device embolization or implantation complications occurred.

Conclusions:

• The ADO II demonstrates feasibility and efficacy for occluding PDA (≥ 2 mm diameter), particularly in smaller children with larger ducts.
• Longer-term follow-up in a larger patient cohort is necessary to confirm safety and long-term outcomes.