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Updated: Jun 21, 2026
Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
Published on: January 19, 2020
Measurement of hemodynamics during postural changes using a new wearable cephalic laser blood flowmeter
Tetsuya Fujikawa1, Osamu Tochikubo, Naoki Kura
1Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Japan. t066033c@yokohama-cu.ac.jp
Background:
Patients with orthostatic hypotension have pathologic hemodynamics related to changes in body posture. A new cephalic laser blood flowmeter that can be worn on the tragus to investigate the hemodynamics upon rising from a sitting or squatting posture was developed.
Methods And Results:
The relationship between cephalic hemodynamics and cerebral ischemic symptoms in 63 subjects in a sitting, squatting, and standing positions using the new device was evaluated. Transient decrease in blood pressure within 15 s after rising to an erect position possibly causes dizziness, syncope, and fall. Subjects exhibiting dizziness upon standing showed a significant decrease in the cephalic blood flow (CBF) and indirect beat-to-beat systolic blood pressure, as monitored by the Finometer, and a significant correlation was observed between the drop ratio (drop value on rising/mean value in the squatting position) of CBF and that of systolic blood pressure.
Conclusions:
This new wearable CBF-meter is potentially useful for estimating cephalic hemodynamics and objectively diagnosing cerebral ischemic symptoms of subjects in a standing posture.
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Preparation of Equipment:
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Monitoring Both Arms:
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