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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Postprostatectomy radiotherapy for prostate cancer.

William M Mendenhall1, Randal H Henderson, R Charles Nichols

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA. mendwm@shands.ufl.edu

American Journal of Clinical Oncology
|August 5, 2009
PubMed
Summary
This summary is machine-generated.

Adjuvant postoperative radiotherapy (RT) after prostatectomy improves outcomes for pT3N0 patients. Salvage RT is recommended for recurrence, with optimal dosing balancing efficacy and toxicity.

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Published on: November 7, 2025

Area of Science:

  • Oncology
  • Radiation Oncology
  • Urologic Oncology

Background:

  • Radical prostatectomy is a primary treatment for localized prostate cancer.
  • Adjuvant and salvage radiotherapy (RT) play crucial roles in managing post-prostatectomy patients.
  • Understanding optimal RT strategies is vital for improving patient survival and quality of life.

Purpose of the Study:

  • To review the established roles of adjuvant postoperative RT and salvage RT.
  • To evaluate the impact of RT on survival and local-regional control in prostate cancer patients.
  • To define optimal RT dosing and fractionation schedules, considering potential toxicities.

Main Methods:

  • Literature review of studies on adjuvant and salvage radiotherapy after radical prostatectomy.
  • Analysis of data on biochemical progression-free survival, clinical progression-free survival, and local-regional control.
  • Evaluation of overall survival and cause-specific survival benefits associated with RT.
  • Assessment of optimal RT dose, fractionation, and the role of combination therapies.

Main Results:

  • Postoperative RT improves progression-free survival and local-regional control in pT3N0 patients.
  • While overall survival benefit is not yet proven, long-term survival may improve with RT for eligible patients.
  • Optimal postoperative RT dose is approximately 70 Gy in 35 once-daily fractions.
  • Salvage RT is indicated for local-regional recurrence without distant metastasis or biochemical relapse.
  • Higher doses for salvage RT may exceed 70 Gy but are limited by toxicity risks.

Conclusions:

  • Adjuvant RT offers significant benefits for specific prostate cancer patient groups.
  • Salvage RT is a viable option for recurrent disease, with careful dose selection crucial.
  • Androgen deprivation therapy and whole-pelvis RT roles require further investigation for specific high-risk patient subgroups.