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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
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The evolutionary significance of ancient genome duplications

Yves Van de Peer1, Steven Maere, Axel Meyer

  • 1Department of Plant Systems Biology, VIB (Flanders Institute of Biotechnology), Ghent, Belgium. Yves.Vandepeer@psb.vib-ugent.be

Nature Reviews. Genetics
|August 5, 2009
PubMed

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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