Itraconazole in dermatophyte infections: clinical experience in Italy

Approximately 200 patients with clinically and mycologically diagnosed dermatophytoses were treated with itraconazole. The drug was administered at a dose of 100 mg with the main meal. Therapy duration was as follows: tinea corporis and tinea cruris, 14 days; tinea pedis and tinea manuum, 28 days; tinea unguium of hands, three months, and feet, six months; tinea capitis, 30 days. Clinical and mycological control tests (eg, direct microscopy and culture) were performed prior to treatment, at the end of treatment and two and four weeks after the end of treatment. Blood chemistry parameters were measured before and at the end of treatment. The results of the research presented here mirror exactly those of international research and therefore confirm that itraconazole is both active and well tolerated in the treatment of dermatophytoses.