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Probiotics

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

Microbiota Modulation by Antibiotics

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

The Skin Microbiota

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

Biological Methods for Microbial Control

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Updated: Jun 21, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

[Outside-in. Probiotic topical agents].

T Volz¹, T Biedermann

¹Universitäts-Hautklinik Tübingen.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|August 6, 2009

Summary

This summary is machine-generated.

Topical probiotics show promise for treating inflammatory skin conditions like atopic dermatitis. These non-pathogenic microbes applied directly to the skin can enhance natural defenses and promote immune tolerance, offering a new therapeutic avenue.

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Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

Area of Science:

Dermatology
Microbiology
Immunology

Context:

Oral probiotics have limited success in treating atopic dermatitis, unlike their established efficacy in gastrointestinal disorders.
Emerging research highlights the potential of non-pathogenic microbes, including probiotics, for dermatological applications.
The skin's natural microflora shares common pathways with probiotics, suggesting synergistic therapeutic potential.

Purpose:

To explore the therapeutic potential of topical probiotics and non-pathogenic microbes in dermatology.
To characterize common pathways utilized by probiotics, skin microflora, and other non-pathogenic microbes for enhanced therapeutic strategies.
To investigate the role of these microbes in modulating skin immune responses and promoting tolerance.

Summary:

Probiotics and non-pathogenic microbes, similar to the skin's resident microflora, do not induce inflammatory skin responses.
These microbes exert effects directly at the application site, activating natural defense mechanisms and promoting immunological tolerance.
The topical application of probiotics is a promising strategy for managing excessive inflammatory skin reactions.

Impact:

Recent clinical trials demonstrate the efficacy of topical probiotics as a novel therapeutic concept for various skin disorders.
This approach offers a new paradigm for the prophylaxis and treatment of inflammatory skin conditions.
Understanding the mechanisms of action can lead to more effective and targeted microbial therapies in dermatology.