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Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implications
Yi-Ping Wang1, Hsin-Ming Chen, Ru-Cheng Kuo
1Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.
Oral verrucous hyperplasia (OVH) is a premalignant lesion often linked to areca quid chewing and smoking. Mass-typed OVH lesions show a higher malignant transformation rate, necessitating prompt treatment.
Area of Science:
- Oral pathology
- Oncology
- Dermatology
Background:
- Oral verrucous hyperplasia (OVH) is a recognized premalignant oral lesion.
- OVH has the potential to progress into oral squamous cell carcinoma.
Purpose of the Study:
- To evaluate clinicopathological features of OVH.
- To determine the 5-year malignant transformation rate of OVH lesions.
- To identify risk factors and lesion types associated with malignant transformation.
Main Methods:
- Sixty consecutive OVH cases diagnosed between 2003 and 2004 were analyzed.
- Clinicopathological data and follow-up information were collected.
- Lesions were classified by type (plaque vs. mass) and transformation rates were calculated.
Main Results:
- OVH predominantly affects individuals aged 40-69 (84%).
- Buccal mucosa (48%) is the most common site; areca quid chewing (91%) and smoking (89%) are highly prevalent.
- Mass-typed OVH lesions exhibited a significantly higher malignant transformation rate (17%) compared to plaque-typed lesions (3%).
Conclusions:
- OVH is strongly associated with areca quid chewing and smoking, frequently occurring on the buccal mucosa.
- The overall 5-year malignant transformation rate for OVH was 10%.
- Mass-typed OVH lesions require immediate therapeutic intervention due to their higher malignant potential.
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