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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Reactions02:06

Allergic Reactions

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Updated: Jun 21, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Pathogenesis of atopic dermatitis: new developments.

Thomas Bieber1, Natalija Novak

  • 1Department of Dermatology and Allergy, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany. Thomas.Bieber@ukb.uni-bonn.de

Current Allergy and Asthma Reports
|August 7, 2009
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) involves complex gene and environmental interactions affecting the skin barrier and immune system. Recent research focuses on understanding these genetic factors and immune mechanisms in AD pathogenesis.

Related Experiment Videos

Last Updated: Jun 21, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a complex skin condition influenced by multiple gene-gene and gene-environment interactions.
  • The intricate pathophysiology of AD contributes to a wide range of risk and trigger factors, yet remains incompletely understood.
  • Genetic factors impacting epidermal skin barrier function and the interplay between innate and adaptive immunity are key research areas.

Purpose of the Study:

  • To review and summarize the latest research findings on the genetic and immunological aspects of atopic dermatitis.
  • To provide an updated overview of the complex pathophysiologic network in AD.
  • To highlight recent advancements in understanding gene-environment interactions in AD.

Main Methods:

  • Literature review of recent studies on atopic dermatitis.
  • Synthesis of current knowledge on genetic modifications related to skin barrier dysfunction.
  • Analysis of research on the interaction between innate and adaptive immunity in AD.

Main Results:

  • Recent studies have identified significant genetic modifications contributing to epidermal barrier defects in AD.
  • Intensive research has elucidated complex interactions between innate and adaptive immune mechanisms in AD.
  • The review consolidates current understanding of the multifactorial nature of AD.

Conclusions:

  • Understanding the genetic underpinnings and immune system interactions is crucial for comprehending AD.
  • Recent findings offer deeper insights into the complex network of factors contributing to atopic dermatitis.
  • Further research into these areas holds promise for improved AD management and treatment strategies.