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Published on: July 5, 2017
Anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark
Saikat Dewanjee1, Vivekananda Mandal, Ranabir Sahu
1Department of Pharmaceutical Technology, Division of Pharmacognosy, Pharmacognosy and Phytotherapy Research Laboratory, Jadavpur University, Kolkata, India. s.dewanjee@yahoo.com
Abstract:
In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-α and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced paw oedema and cotton pallet granuloma, respectively.