Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessment and Optimization of Force Fields for Glycine Polymorphism and Solution Properties.

Journal of chemical theory and computation·2026

Same author

Effect of Total Wrist Arthroplasty Alignment on Wrist Range of Motion and Component Impingement.

The Journal of hand surgery·2026

Same author

LinkML: an open data modeling framework.

GigaScience·2025

Same author

Assessing Axial Instability of Bennett Fractures and Direct Comparison of Two K-wire Fixation Constructs: A Paired Cadaveric Biomechanical Analysis.

Hand (New York, N.Y.)·2025

Same author

Striking a Balance With Business and Engineering Content in Biomedical Engineering Capstone Design.

Journal of biomechanical engineering·2025

Same author

Academic Oral and Maxillofacial Surgery Practice Models in United States Dental Schools.

Oral and maxillofacial surgery clinics of North America·2025

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

Micromechanics of postmortem-retrieved cement-bone interfaces.

Mark A Miller¹, Alan W Eberhardt, Richard J Cleary

¹Department of Orthopedic Surgery, SUNY Upstate Medical University, Institute for Human Performance, Syracuse, New York 13210, USA.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society

|August 7, 2009

Summary

This summary is machine-generated.

The cement-bone interface in hip replacements weakens significantly over time. Micromechanical testing revealed reduced stiffness and strength in retrieved implants compared to new ones, indicating potential issues with load transfer.

More Related Videos

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Jun 21, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Area of Science:

Biomaterials Science
Orthopedic Biomechanics
Tissue Engineering

Background:

The cement-bone interface is critical for load transfer in cemented implants.
Micromechanical behavior of aged cement-bone interfaces is poorly understood.
Understanding this interface is vital for implant longevity and patient outcomes.

Purpose of the Study:

To investigate the micromechanical properties of the cement-bone interface after in vivo service.
To compare the mechanical response of postmortem retrieved specimens with laboratory-prepared specimens.
To identify factors influencing the mechanical behavior of the cement-bone interface.

Main Methods:

Mechanical testing (tensile and compressive loading) of postmortem retrieved cement-bone specimens.
CT-based stereology for quantifying cement-bone interface morphology.
Comparison with laboratory-prepared specimens simulating immediate postoperative conditions.

Main Results:

Cement-bone interfaces from postmortem retrievals exhibited significantly lower stiffness and strength than laboratory-prepared specimens.
Retrieved interfaces were highly compliant under tension and compression, with very low tensile strength (0.21 ± 0.32 MPa).
Interface contact and intersection fractions explained 71% of the variability in mechanical response (p < 0.0001).

Conclusions:

In vivo service leads to a weaker and more compliant cement-bone interface.
Bony remodeling around the implant may reduce cement-bone contact, compromising interface integrity.
Findings suggest potential implications for cemented implant stability and longevity.