[BRCA 1 and BRCA 2 gens in breast cancer]
1Von Rotem Kreuz Krankenhaus Maingau Frankfurt am Main, Germany.
Abstract:
The development of molecular genetics last years brought a better understanding of the mechanisms of breast cancer development. "The hereditary" breast cancer is very much connected with the BRCA 1 and BRCA 2 gene mutations. Recent studies suggest a role for BRCA 1 and BRCA 2 in transcriptional regulation, as it possesses a conserved NH2 terminal ring finger domain and an COOH domain. This role would be consistent with the reported localization of the BRCA 1/BRCA 2 protein to the nucleus. The BRCA 1 and BRCA 2 may play an as yet undefined protective role in cells, as it is expressed in epithelial cells undergoing high levels of proliferation in association with differentiation.
More Related Videos
Related Concept Videos
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancers Originate from Somatic Mutations in a Single Cell
Cancers Originate from Somatic Mutations in a Single Cell


