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Updated: Jun 21, 2026
09:43
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Metastatic phyllodes tumor causing small-bowel obstruction.
Ronan J Kelly1, Ciara Barrett, Niall Swan
1National Cancer Institute, Bethesda, MD 20892, USA. kellyro@mail.nih.gov
Clinical Breast Cancer
|August 8, 2009
Summary
Metastatic cystosarcoma phyllodes, a rare breast tumor, can spread to the small intestine, causing obstruction. This case highlights an extremely rare ileum metastasis, emphasizing the need for vigilant follow-up in high-risk patients.
Area of Science:
- Oncology
- Pathology
Background:
- Cystosarcoma phyllodes is a rare fibroepithelial breast neoplasm, constituting 0.5%-1.0% of breast carcinomas.
- Malignant variants represent approximately 25% of cases, with common sites of metastasis including the lung, pleura, bone, and liver.
Observation:
- Metastatic spread to the small intestine from cystosarcoma phyllodes is exceptionally rare.
- This report details a unique instance of metastatic phyllodes breast tumor causing small bowel obstruction, specifically involving the ileum, a site not previously documented for such metastasis.
Findings:
- Phyllodes tumors are histologically classified into benign, intermediate, and malignant subtypes.
- The study discusses factors contributing to the dedifferentiation of phyllodes tumors from a benign to a malignant phenotype.
Implications:
- This case underscores the potential for rare metastatic patterns of cystosarcoma phyllodes, necessitating thorough diagnostic evaluation for unexplained gastrointestinal symptoms in affected patients.
- Effective chemotherapeutic regimens and regular clinical and radiologic surveillance are crucial for managing patients with poor prognostic indicators associated with phyllodes tumors.
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