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Paramagnetic Gd-based gold glyconanoparticles as probes for MRI: tuning relaxivities with sugars

Marco Marradi1, David Alcántara, Jesús Martínez de la Fuente

  • 1Laboratory of GlycoNanotechnology, CIC biomaGUNE/CIBER-BBN and IIQ-CSIC, Parque Tecnológico de San Sebastián, San Sebastián, Spain.

Chemical Communications (Cambridge, England)
|August 8, 2009
PubMed

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...