Related Experiment Video
Updated: Jun 21, 2026
08:58
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
[Investigation of Enterococcus faecalis antimicrobial resistance]
1Servicio de Microbiología, Hospital Universitario Reina Sofía, Córdoba (España). mi1carom@uco.es
Summary
This study on Enterococcus faecalis antibiotic resistance found high sensitivity to betalactamics and 100% sensitivity to vancomycin and linezolid, though aminoglycoside resistance requires monitoring.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Research
Context:
- Enterococcus faecalis is a common cause of hospital-acquired infections.
- Antibiotic resistance in E. faecalis poses a significant public health challenge.
- This study analyzed E. faecalis isolates from clinical samples over a four-year period.
Purpose:
- To determine the antibiotic resistance patterns of Enterococcus faecalis.
- To assess the susceptibility of E. faecalis to various antibiotic classes.
- To provide data for guiding antimicrobial therapy and infection control.
Summary:
- A total of 3,641 E. faecalis isolates from urine, blood, and wound swabs were analyzed.
- High sensitivity rates were observed for betalactamics (98.04%).
- Highest resistance rates were to aminoglycosides (33.82%-48.01%), while vancomycin and linezolid showed 100% sensitivity.
Impact:
- Vancomycin resistance is currently not a significant concern but warrants ongoing surveillance.
- Findings can inform empirical treatment guidelines for E. faecalis infections.
- Highlights the need for continued monitoring of antibiotic resistance trends.
Related Concept Videos
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:28Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...