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Hepatobiliary abnormalities in pediatric patients with sickle cell disease
Roberto Paulo Almeida1, Cibele Dantas Ferreira, Joseni Conceição
1Postgraduate Program in Medicine and Health, Federal University of Bahia, Brasil.
Objective:
to describe clinical, laboratory and ultrasonographic abnormalities in the hepatobiliary system of pediatric patients with sickle cell disease in the city of Salvador, Brazil.
Material And Methods:
pediatric patients with sickle cell disease were clinically evaluated, their charts were reviewed and findings of supplementary tests were examined to identify hepatobiliary abnormalities.
Results:
a total of 134 patients were evaluated, 65 of whom (48.9%) presented hepatomegalia. Elevated transaminases were present in 42.2% and 11.4% presented cholelithiasis. There was a statistically significant association between the presence of hepatomegalia and SS homozygotes and between cholelithiasis and patients over 10 years of age (p = 0.01 and p = 0.00, respectively).
Conclusion:
hepatobiliary abnormalities in patients with sickle cell disease were common, particularly in patients with hemoglobin SS and in adolescent patients.
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