Related Experiment Video

Updated: Jun 21, 2026

Microvascular Embolism Mouse Model for In Vivo Two-photon Microscopy Using Fluorescent Polystyrene Microspheres
08:29

Microvascular Embolism Mouse Model for In Vivo Two-photon Microscopy Using Fluorescent Polystyrene Microspheres

Published on: November 21, 2025

[Microemboli as a cause of postoperative deliria and cognitive disorders in surgical practice]

A G Polunina, A V Begachev

    Anesteziologiia I Reanimatologiia
    |August 12, 2009
    PubMed

    Insights

    Intraoperative microemboli are linked to postoperative delirium and cognitive issues. The left temporal and occipital brain regions are particularly susceptible to this ischemia, requiring further research into prevention strategies.

    Area of Science:

    • Neuroscience
    • Neurology
    • Surgical Research

    Context:

    • Contemporary clinical and experimental studies indicate a significant link between intraoperative microemboli and adverse neurological outcomes.
    • Postoperative delirium and cognitive disorders are increasingly recognized complications following surgical procedures.

    Purpose:

    • To analyze the contribution of intraoperative microemboli to postoperative neurological deficits.
    • To highlight the vulnerability of specific brain regions, namely left temporal and occipital structures, to intraoperative ischemia.
    • To underscore the need for further investigation into preventative measures against intraoperative microembolism.

    Summary:

    • Intraoperative microemboli are a significant factor in the development of postoperative delirium and cognitive impairment.
    • Ischemia affecting the left temporal and occipital brain regions during surgery can lead to transient psychoses and hypomnesia.
    • Current research suggests a need for enhanced strategies to prevent intraoperative microembolism and its associated neurological sequenae.

    Impact:

    • This research emphasizes the critical role of microembolism in surgical patient outcomes.
    • Identifying vulnerable brain regions can inform targeted neuroprotective strategies.
    • Further research into prevention may lead to improved patient safety and reduced incidence of postoperative cognitive dysfunction.

    More Related Videos

    A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration08:17

    A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

    Published on: February 27, 2018

    Related Concept Videos

    Pulmonary Embolism I: Introduction01:29

    Pulmonary Embolism I: Introduction

    Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
    Pulmonary Embolism I: Introduction01:19

    Pulmonary Embolism I: Introduction

    A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

    Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
    Pulmonary Embolism III: Nursing Management01:27

    Pulmonary Embolism III: Nursing Management

    A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
    Peripheral Artery Disease V: Postoperative Nursing Management01:23

    Peripheral Artery Disease V: Postoperative Nursing Management

    During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
    Aneurysm IV: Nursing Management01:22

    Aneurysm IV: Nursing Management

    Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...