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Updated: Jun 21, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A
Vasudha Sharma1, Gilbert T Kelly, Jennifer Foulke-Abel
1Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
Abstract:
Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.
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