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[Breast carcinoma, apocrine variety]
1Hospital Israelita Albert Einstein, Serv. de Anatomia Patológica, São Paulo.
Revista Paulista De Medicina
|September 1, 1990
Summary
This case report details a breast carcinoma with skin infiltration and apocrine features. The cancer cells showed positive markers for casein and epithelial membrane antigen, indicating mammary cell origin.
Area of Science:
- Oncology
- Pathology
- Dermatology
Background:
- Breast carcinoma is a common malignancy with diverse histological presentations.
- Skin infiltration in breast cancer can indicate advanced disease and affect prognosis.
Observation:
- A rare case of breast carcinoma involving the skin was examined.
- Microscopic analysis revealed apocrine features in all neoplastic cells.
- Immunohistochemistry was performed to identify specific cellular markers.
Findings:
- Carcinoma cells exhibited strong positive staining for casein, a protein found in mammary secretions.
- Epithelial membrane antigen (EMA) was also strongly positive in carcinoma cells and glandular secretions.
- The presence of these markers confirmed a mammary cell origin for the tumor.
Implications:
- This case highlights the importance of immunohistochemistry in diagnosing breast carcinoma with unusual histological features.
- Understanding the expression of casein and EMA in skin-infiltrating breast cancer can aid in accurate diagnosis and treatment planning.
- Further research into apocrine breast carcinomas may reveal specific therapeutic targets.