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Unraveling the human embryonic stem cell phosphoproteome
Andrew P Hutchins1, Paul Robson
1Stem Cell & Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Cell Stem Cell
|August 12, 2009
Abstract:
The human embryonic stem cell (hESC) transcriptome is well described, but minimal proteome characterization is available. In this issue of Cell Stem Cell, Brill et al. (2009) and Van Hoof et al. (2009) describe the hESC phosphoproteome and its changes upon differentiation.
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00:58Embryonic Stem Cells
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
00:57Embryonic Stem Cells
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...