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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

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Published on: February 18, 2016

Differences between nicotine and cocaine-induced conditioned place preferences.

H Sershen1, A Hashim, A Lajtha

  • 1Nathan Kline Institute, Orangeburg, NY 10962, USA. Sershen@nki.rfmh.org

Brain Research Bulletin
|August 12, 2009
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Summary

Drug preference mechanisms differ between nicotine and cocaine. Receptor antagonists differentially inhibit conditioned place preference (CPP), indicating distinct neurochemical pathways for each drug.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Previous studies indicated distinct neurotransmitter changes in the brain following nicotine and cocaine exposure.
  • These differences suggested unique reward and preference mechanisms for each drug.
  • Drug preference is influenced by various factors, including neurotransmitters and their receptors.

Purpose of the Study:

  • To compare the inhibition of nicotine and cocaine preference using receptor subtype antagonists.
  • To investigate whether the neurochemical factors modulating drug preference are drug-specific.
  • To determine the role of specific neurotransmitter systems in mediating nicotine versus cocaine preference.

Main Methods:

  • Conditioned place preference (CPP) was used to assay drug preference in mice.
  • CPP was inhibited using antagonists for nicotinic acetylcholine, muscarinic acetylcholine, dopamine D1, and alpha noradrenergic receptors.
  • The degree of CPP inhibition by each antagonist was compared between nicotine and cocaine.

Main Results:

  • Cocaine-induced CPP was generally stronger than nicotine-induced CPP.
  • Antagonists showed differential effects on nicotine and cocaine CPP inhibition.
  • Mecamylamine and phentolamine significantly inhibited nicotine CPP (100%) but had minimal effect on cocaine CPP (20% and 0%, respectively).
  • Atropine and SCH23390 inhibited both nicotine and cocaine CPP to a similar extent.

Conclusions:

  • Multiple receptor systems and neurotransmitters are involved in drug preference.
  • Some neurochemical components are essential for drug preference, while others can be partially substituted.
  • The specific neurochemical systems influencing drug preference differ between nicotine and cocaine.