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ASSOCIATION BETWEEN GALECTIN-3 AND MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES MELLITUS: A COMPARATIVE STUDY.
A Manzoorudeen1, I Ismail1, A Hashim1
1Department of Medical Laboratory Science, College of Health Sciences, Gulf Medical University, Ajman, UAE.
Georgian Medical News
|February 13, 2026
Summary
Serum galectin-3 levels are higher in type 2 diabetes mellitus (T2DM) patients with microvascular complications. However, galectin-3 is not an independent predictor of these complications after adjusting for BMI and glycemic control.
Area of Science:
- Endocrinology
- Nephrology
- Immunology
Background:
- Galectin-3, a lectin involved in inflammation and fibrosis, is implicated in type 2 diabetes mellitus (T2DM) pathogenesis and its microvascular complications.
- Elevated galectin-3 is observed in inflammatory and fibrotic conditions.
Purpose of the Study:
- To investigate the association between serum galectin-3 levels and microvascular complications in T2DM patients.
- To determine if this association persists after controlling for clinical factors.
Main Methods:
- A comparative cross-sectional study of 64 participants (32 T2DM with microvascular complications, 32 controls).
- Serum galectin-3 measured via ELISA.
- Clinical parameters (BMI, HbA1c, etc.) and microalbuminuria assessed.
- Multivariable linear regression analysis performed.
Main Results:
- Serum galectin-3 levels were significantly higher in T2DM patients with microvascular complications versus controls (p<0.001).
- Galectin-3 showed strong positive correlations with microalbuminuria (p<0.001) and moderate correlation with HbA1c (p<0.001).
- Galectin-3 was not independently associated with microalbuminuria after adjustment for BMI, HbA1c, and age (p=0.197); HbA1c remained significant (p<0.001).
Conclusions:
- Elevated serum galectin-3 in T2DM patients with microvascular complications does not independently predict these complications.
- Galectin-3 may indicate underlying metabolic and inflammatory burden rather than being an independent predictor.
- Glycemic control (HbA1c) remains a key independent predictor of microvascular complications in T2DM.
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