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EEG sleep activities react topographically different to GABAergic sleep modulation by flunitrazepam: relationship to
1Abteilung für klinische Neurophysiologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, BRD.
Neuropsychobiology
|January 1, 1990
Abstract:
Spectral analysis was performed to study the response of various EEG sleep activities to a modification of GABAergic sleep regulation by flunitrazepam. We observed sleep stage- and sleep cycle-dependent differences in the topographic distribution of the reactions. An increase in power density was found in the frontal regions for the alpha 2 and sigma 1 frequency band whereas a decrease in power density was emphasized in the posterior regions for the delta and alpha 1 frequency band. These topographic differences might be related to the regional distribution of benzodiazepine receptor subtypes.