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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Updated: Jun 21, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

[Hematopoietic stem cell grafts.].

K O Gudmundsson, L Thorsteinsson, A Haraldsson

    Laeknabladid
    |August 12, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Standardized in vitro methods for evaluating hematopoietic stem cell grafts from umbilical cord blood were established. These methods ensure reliable assessment of stem cell graft quality for transplantation.

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    Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
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    Published on: December 8, 2023

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    In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
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    In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

    Published on: February 16, 2024

    Area of Science:

    • Hematology
    • Cell Biology
    • Transplantation Science

    Context:

    • Stem cell transplantation is increasingly used for hematologic disorders and malignancies.
    • Peripheral blood stem cell transplantation is replacing autologous bone marrow transplantation.
    • Umbilical cord blood stem cells offer an alternative source for transplantation.

    Purpose:

    • To standardize in vitro methods for evaluating stem cell grafts.
    • To assess the quality of umbilical cord blood mononuclear cells for transplantation.

    Summary:

    • Mononuclear cells (MNC) were isolated from 57 umbilical cord blood samples.
    • Hematopoietic stem cell proportion (CD34+) and clonogenic cells (BFU-E, CFU-GM) were quantified.
    • In vitro methods were validated for assessing stem cell graft quality, including post-cryopreservation viability and cell counts.

    Impact:

    • Established reliable in vitro assays for hematopoietic stem cell graft evaluation.
    • Ensures consistent quality assessment of umbilical cord blood stem cell grafts.
    • Supports the broader application of umbilical cord blood stem cell transplantation.