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Updated: Jun 21, 2026
10:01
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
Published on: August 2, 2022
Summary
Meningeal carcinomatosis, a lung adenocarcinoma complication, can manifest as acute confusional state. This case highlights rapid neurological decline and the importance of cerebrospinal fluid analysis in diagnosing neoplastic meningitis.
Area of Science:
- Neurology
- Oncology
- Pathology
Context:
- Presents a rare case of meningeal carcinomatosis as the initial manifestation of lung adenocarcinoma.
- Highlights the diagnostic challenge of neurological symptoms preceding a confirmed lung cancer diagnosis.
Purpose:
- To report a case of acute confusional state as the first symptom of meningeal carcinomatosis.
- To emphasize the utility of cerebrospinal fluid analysis in identifying neoplastic meningitis.
Summary:
- A 69-year-old man with adenocarcinoma of the lung presented with acute confusional state and neck pain, indicative of meningeal carcinomatosis.
- Cerebrospinal fluid analysis revealed neoplastic cells, confirming the diagnosis. Despite prompt readmission, the patient experienced rapid deterioration and died within five days.
Impact:
- Underscores the critical role of cerebrospinal fluid cytology in diagnosing leptomeningeal disease.
- Illustrates the potential for neurological symptoms to be the primary presentation of advanced lung cancer.
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