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Updated: Jun 21, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
[Peptic ulcer perforations, University Hospital of Iceland 1989-1995.]
Objective:
In this audit we looked at patients who came in to the University Hospital of Iceland, diagnosed to have perforated peptic ulcer, with the aim to gain information about the patients and the treatment.
Material And Methods:
Information was from patients' notes, of 72 patients presenting with perforated peptic ulcer, from 1 January 1989 to 31 December 1995. Mean age of patients was 59 years. Male: female 1:1.
Results:
Twenty nine persent of the patients had history of previous peptic ulcer. One third of the patients were receiving NSAID at the time of perforation, 54% had gastric perforation and 45% duodenal perforation. Fourty four (64%) did undergo laparotomy and 25 (36%) laparoscopy. Of the 25, 11 operations were converted to laparotomy. Mortality was 13%. Patients, that had laparoscopic treatment, were discharged 2.3 days earlier on average, compared to those undergoing laparotomy. Thirty one (45%) patients had concomitant disease(s).
Conclusions:
A large proportion of patients coming to hospital with perforated peptic ulcers are older people, many with serious concomitant diseases. Laparoscopic treatment of perforated ulcers are equal to lapotomy, altough laporoscopic treatment shows a trent towards shortening of postoperative treatment in hospital.
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Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

