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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Related Experiment Video

Updated: Jun 21, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Calcineurin as a nociceptor modulator.

Howard S Smith1

  • 1Albany Medical College, Department of Anesthesiology, Albany, NY 12208, USA. smithh@mail.amc.edu

Pain Physician
|August 12, 2009
PubMed
Summary

Calcineurin influences pain perception by affecting ion channels and gene expression. Understanding its role in nociception could reveal new pain relief targets.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Calcineurin is implicated in various physiological processes.
  • Its role in nociception (pain signaling) is complex and not fully understood.
  • Calcineurin affects ion channels like TRESK and signaling pathways such as NFAT.

Purpose of the Study:

  • To explore the multifaceted role of calcineurin in nociceptive processes.
  • To investigate how calcineurin modulates pain signaling pathways.
  • To identify potential therapeutic targets for pain management related to calcineurin.

Main Methods:

  • Review of existing literature on calcineurin's involvement in nociception.
  • Analysis of calcineurin's effects on glial resting membrane potential via TRESK channels.

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Related Experiment Videos

Last Updated: Jun 21, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

  • Examination of calcineurin's role in NFAT activation and downstream gene expression.

    • Main Results:

    • Calcineurin's influence on TRESK channels may facilitate nociception.
    • Calcineurin regulates NFAT signaling, leading to pronociceptive gene transcription.
    • Calcineurin inhibitors can induce pain (CIPS), indicating a role in pain modulation.

    Conclusions:

    • Calcineurin possesses dual functions in nociception, potentially promoting or inhibiting pain.
    • Further research into calcineurin's physiology is crucial for developing novel analgesic strategies.
    • Targeting calcineurin pathways may offer new avenues for treating pain and discomfort.