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Related Experiment Video

Updated: Jun 21, 2026

A Surgical Approach for Optic Nerve Crush in a Rabbit Model

A Surgical Approach for Optic Nerve Crush in a Rabbit Model

Published on: July 8, 2025

Clinical approach to optic neuropathies.

Raed Behbehani¹

¹Neuro-Ophthalmology Service, Department of Ophthalmology, Ibn Sina Hospital, PO Box 1262, Kuwait City, Kuwait. r_behbehani@hotmail.com

Clinical Ophthalmology (Auckland, N.Z.)

|August 12, 2009

Summary

Optic neuropathy, a common cause of vision loss, is diagnosed clinically. Understanding the onset and signs aids in identifying the cause and guiding investigations like visual field testing and neuroimaging.

Keywords:

Leber’s optic neuropathy arteritic anterior ischemic optic neuropathy (AION)dominant optic atrophy multiple sclerosis non-arteritic anterior ischemic optic neuropathy (NAION)optic neuritis optic neuropathy optical coherence tomography radiation optic neuropathy recessive optic atrophy traumatic optic neuropathy

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Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Published on: May 12, 2011

Area of Science:

Ophthalmology
Neurology

Background:

Optic neuropathy is a significant cause of vision loss.
Diagnosis relies heavily on clinical presentation and patient history.

Purpose of the Study:

To outline the diagnostic approach to optic neuropathy.
To highlight key clinical signs and investigations.

Main Methods:

Clinical assessment including history and examination.
Visual field testing (manual kinetic or automated static perimetry).
Neuro-imaging (brain and orbit).
Emerging technologies: multifocal visual evoked potentials and optic coherence tomography.

Main Results:

Rapid onset suggests demyelinating, inflammatory, ischemic, or traumatic causes.
Gradual onset suggests compressive, toxic/nutritional, or hereditary causes.
Classic signs include visual field defects, dyschromatopsia, and abnormal pupillary response.

Conclusions:

Clinical evaluation is paramount for diagnosing optic neuropathy.
Ancillary tests like visual field testing and neuroimaging are crucial for etiological diagnosis and management.
Advanced imaging and electrophysiological tests offer further insights.