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Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Published on: May 12, 2011

Optic nerve sheath meningocele.

Juan Carlos Mesa-Gutiérrez¹, Silvia Muñoz Quiñones, Jorge Arruga Ginebreda

¹Department of Ophthalmology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Clinical Ophthalmology (Auckland, N.Z.)

|August 12, 2009

Summary

Dural ectasia of the optic nerve sheath can cause visual loss. Acetazolamide treatment showed good results, suggesting surgery may not always be necessary for this condition.

Keywords:

optic nerve optic nerve meningocoele optic nerve tumors perineural subaracnoid space

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Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

Area of Science:

Ophthalmology
Neurology

Background:

Optic nerve sheath dural ectasia is a rare condition characterized by fluid accumulation within the optic nerve sheath.
It can lead to visual disturbances, including vision loss.

Observation:

A 53-year-old male presented with a 5-month history of left eye visual loss.
Funduscopy revealed choroidal folds and optic disc elevation; MRI confirmed a dilated, fluid-filled optic nerve sheath.
Physical examination and CSF analysis were normal.

Findings:

The patient was diagnosed with optic nerve sheath dural ectasia.
Treatment with acetazolamide resulted in good anatomical and functional outcomes over a 2-year follow-up.
This suggests a potential role for carbonic anhydrase inhibitors in managing this condition.

Implications:

Acetazolamide may be a viable alternative to optic nerve decompression surgery for optic nerve sheath dural ectasia.
Surgical intervention might be reserved for cases with rapid or progressive optic nerve dysfunction.
Further research into the role of cerebrospinal fluid protein levels and osmotic gradients is warranted.