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Dexamethasone in unexplained infertility
Sanam Moradan1, Raheb Ghorbani
1Department of Obstetrics and Gynecology, Amir Hospital, Semnan, Iran. sm42595@yahoo.com
Saudi Medical Journal
|August 12, 2009
Summary
Adding dexamethasone to clomiphene citrate treatment significantly increased pregnancy rates in women with unexplained infertility undergoing ovulation induction and intrauterine insemination (IUI). This combination therapy offers a promising option for improving fertility outcomes.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatment
Background:
- Unexplained infertility affects a significant number of couples seeking fertility treatment.
- Current ovulation induction protocols may have limited success rates.
Purpose of the Study:
- To evaluate the efficacy of dexamethasone as an adjunct therapy in ovulation induction for unexplained infertility.
Main Methods:
- A prospective study involving 124 women with unexplained infertility undergoing one cycle of ovulation induction and intrauterine insemination (IUI).
- Participants were divided into two groups: clomiphene citrate (CC) + dexamethasone (Group I, n=42) and CC alone (Group II, n=66).
- Clinical pregnancy rates were compared between the two groups.
Main Results:
- The clinical pregnancy rate in the dexamethasone group (Group I) was 21.4%, compared to 4.5% in the control group (Group II).
- A statistically significant difference was observed between the groups (p=0.0085), with a relative risk of 4.71 for pregnancy in the dexamethasone group.
Conclusions:
- Combining dexamethasone with clomiphene citrate and IUI significantly enhances pregnancy rates in women with unexplained infertility.
- Dexamethasone may be a valuable addition to ovulation induction protocols for improving fertility outcomes.
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