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Updated: Jun 21, 2026
08:51
Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
[The age as a predictive factor in in vitro fertilization cycles]
Luiz Mauro Oliveira Gomes1, Aparecida Dos Santos Canha, Artur Dzik
1Laboratório de Embriologia, Clínica Reproferty, São José dos Campos, SP, Brasil.
Summary
Patient age significantly impacts in vitro fertilization (IVF) success. Women over 40 experience lower oocyte yield, fewer transferred embryos, and reduced pregnancy rates, highlighting age as a key predictor in assisted reproduction.
Area of Science:
- Reproductive Medicine
- Infertility Research
- Biostatistics in Healthcare
Context:
- In vitro fertilization (IVF) is a cornerstone of assisted reproductive technology.
- Patient age is a known factor influencing fertility outcomes.
- Evaluating age-specific predictors is crucial for optimizing IVF success rates.
Purpose:
- To assess the predictive value of patient age on outcomes in an in vitro fertilization (IVF) program.
- To analyze the correlation between age groups and key IVF metrics.
- To determine if age influences oocyte yield, fertilization, embryo quality, and pregnancy rates.
Summary:
- A transversal study included 302 women aged 24-46 undergoing IVF.
- Patients were grouped by age: <=35, 36-39, and >=40.
- Evaluated oocyte count, fertilization rates, embryo quality, embryo transfer numbers, and pregnancy rates using statistical analysis.
Impact:
- Age significantly affects the number of oocytes collected and embryos transferred.
- Women aged 40 and above showed significantly lower pregnancy rates compared to younger groups.
- Patient age is a critical predictive factor for IVF success, especially for women over 40.
Related Concept Videos
01:24In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
02:07Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
01:28Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
01:23Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
01:21Nondisjunction
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
01:57Meiosis II
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...