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Updated: Aug 5, 2026
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Insights about use of p57 in differentiation between complete and partial hydatidiform mole: a scoping review
Isabelle Sasso Teixeira1, Sheldon Rodrigo Botogoski1, Renato Nisihara1
1Universidade Federal do Paraná Paraná Brazil Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Objective:
To assess the utility of p57 in differentiating histological subtypes of hydatidiform mole and its applicability in clinical practice.
Methods:
A scoping review was conducted following the Joanna Briggs Institute methodology and PRISMA-ScR guidelines. The article search was conducted in the PubMed, EMBASE, BVS, Cochrane, Web of Science, and Scopus databases. Studies published between 2015 and 2025 that evaluated the use of p57 in suspected cases of hydatidiform mole were included.
Results:
Nine studies met the inclusion criteria. Most demonstrated high specificity of p57 for CHM diagnosis and a significant reduction in diagnostic discordance compared to morphology alone. However, p57 does not distinguish PHM from non-molar abortions. In addition, rare cases of divergent p57 expression were reported, associated with genetic alterations that may require complementary evaluation using molecular techniques.
Conclusion:
IHC for p57 is a widely accessible, low-cost, and effective tool in clinical practice, particularly useful in resource-limited settings. Its routine use, in association with morphology and molecular methods when available, contributes to more accurate diagnoses and safer clinical management of GTDs.
